Nutritional Support for Mental Wellbeing
Daily doses of 1-2 grams of Omega-3 fatty acids with an EPA/DHA ratio of at least 2:1 are now recommended to support mood balance and as an effective preventative measure, even in vulnerable populations. These guidelines have recently been developed by an international panel of mental health experts.
The Omega-3 status of each individual is variable depending on diet, gender, age and metabolic function, making dosing recommendations complex. However, the panel advised starting with a dose of at least 1g pure EPA or an EPA/DHA ratio of at least 2:1 as being “crucial” to Omega-3 PUFAs mood balancing effects.1 If tolerated, the dose could be increased to 2g after two weeks for non- or partial responders.
For those people still not responding, it is recommended to evaluate the quality of the fish oil product being prescribed.
“The significant difference in efficacy observed in various conditions could be partly related to the concentration (purity) and quality (product preparation) of n-3 PUFA products, which lead to the discrepancy of bio-availability and pharmacodynamics.”
Another interesting recommendation involved the use of the EPA/DHA ration of 2:1 as an adjunct to other treatments designed to support mood balance.
Dose duration was suggested to be eight weeks depending on patient tolerability.
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1. Guu TW, Mischoulon D, Sarris J, et al. International Society for Nutritional Psychiatry Research Practice Guidelines for Omega-3 Fatty Acids in the Treatment of Major Depressive Disorder. Psychother Psychosom. 2019;88(5):263-273. doi:10.1159/000502652